The Effect of Environmental Perchlorate on Thyroid Function in Pregnant Women
نویسندگان
چکیده
1. Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 2. Division of Diabetes and Endocrinology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 3. Lab. de Endocrinología, Hosp. Nac. De Clínicas, UNC, Córdoba, Argentina 4. Dep. de Endocrinología y Diabetes, Hosp. Univ. de Maternidad y Neonatología, UNC, Córdoba, Argentina
منابع مشابه
The epidemiology of environmental perchlorate exposure and thyroid function: a comprehensive review.
OBJECTIVE To review the epidemiological literature relevant to evaluating the risk of adverse effects on thyroid function associated with environmental perchlorate exposure. METHODS All studies investigating possible adverse effects of environmental perchlorate exposure on thyroid function in adults or in pregnant women and their newborns were critically evaluated. RESULTS There is no credi...
متن کاملPerchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women from Greece.
OBJECTIVE Thyroid hormone, requiring adequate maternal iodine intake, is critical for neurodevelopment in utero. Perchlorate and, less so, thiocyanate decrease uptake of iodine into the thyroid gland by competitively inhibiting the sodium/iodide symporter (NIS). It remains unclear whether environmental perchlorate exposure adversely affects thyroid function in first-trimester pregnant women. ...
متن کاملPerchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women.
CONTEXT Thyroid hormone, requiring adequate maternal iodine intake, is critical for fetal neurodevelopment. Perchlorate decreases thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is unclear whether environmental perchlorate exposure adversely affects thyroid function in pregnant women. Thiocyanate, derived from foods and cigarette smoke, is a less potent compe...
متن کاملThyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California
BACKGROUND Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes within normal reference ranges, have been linked to cognitive function declines in...
متن کاملUrinary Perchlorate and Thyroid Hormone Levels in Adolescent and Adult Men and Women Living in the United States
BACKGROUND Perchlorate is commonly found in the environment and known to inhibit thyroid function at high doses. Assessing the potential effect of low-level exposure to perchlorate on thyroid function is an area of ongoing research. OBJECTIVES We evaluated the potential relationship between urinary levels of perchlorate and serum levels of thyroid stimulating hormone (TSH) and total thyroxine...
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